METFORMIN and SULFONYLUREAS EFFECT on the BLOOD LEVEL of PROSTATE SPECIFIC ANTIGEN
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
Objective: The aim of this study was to investigate the effect of metformin and sulfonylurea on the blood level of prostate specific antigen (PSA).Methods: 26 Type 2 diabetic patients under metformin treatment and 42 patients under sulfonylurea treatment were involved in this study, their ageranges were (50‑83) and (51-73), respectively. The patients were followed for 9 months, and three blood samples were obtained from each patient;after 3, 6 and 9 months. The blood samples were collected in ethylenediaminetetraacetic acid tubes, and the plasma was separated and kept at −20°C.Enzyme-linked immunosorbent assay technique was used to determine the PSA level.Results: Regarding the PSA results of the patients under metformin treatment, the mean values and ranges of the first, second and third samples were0.51 (0.0-2.66), 0.6 (0.0-2.77) and 0.7 (0.0-3.42) ng/ml, respectively. Concerning the PSA results of the patients under sulfonylurea treatment, themean values and the ranges of the first, second and third samples were 3.6 (0.0‑39.2), 4.4 (0.0-46.4) and 5.9 (0.0-67.7) ng/ml, respectively.Conclusion: Metformin and sulfonylureas affected the blood PSA level in the Sudanese Type 2 diabetic patients, but the sulfonylureas had the highest effect.Keywords: Metformin, Sulfonylureas, Risk factors, Prostate cancer.
Authors and Affiliations
Mohammed Elimam Ahamed Mohammed, Yousif Elraih Ahme, Ismat Hassan Ali
Keywords
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