Metformin in type 2 diabetes: where is the evidence?
Journal Title: Journal of Diabetology and Endocrinology - Year 2016, Vol 1, Issue 2
Abstract
Taking into consideration the main evidence available in 2015, Boussageon contest the status of metformin as the first -line treatment for DT2 patients. He contends that as regards macrovascular and microvascular complications, its efficacy has never been proven in a double-blind RCT. This observation leads to a more general interrogation on how anti-diabetes medication is to be assessed.
Authors and Affiliations
Boussageon R
A comparative analysis of pharmacists' self-confidence beliefs for regular U-500 (concentrated) insulin and U-100 insulin
The purpose of this research was to assess pharmacist confidence levels in the accurate and safe counseling on Humulin R regular U-500 (concentrated) insulin compared to U-100 insulin. The investigators developed a 34-it...
Long-term correction of diabetic hyperglycemia through glucose-responsive hepatic insulin production using lentivirus
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune destruction of the insulin-producing β cells of the pancreas. Insulin gene therapy is a promising strategy capable of overcoming the limitations of current trea...
Metformin in type 2 diabetes: where is the evidence?
Taking into consideration the main evidence available in 2015, Boussageon contest the status of metformin as the first -line treatment for DT2 patients. He contends that as regards macrovascular and microvascular complic...
Disuse osteoporosis: A better understanding of pathophysiology may lead to potential therapies
Amputation results in mechanical unloading of a previously weight bearing limb with subsequent focal decrease in bone mineral density (BMD), and the development of disuse osteoporosis. We report the case of a 44-year-old...
Protocol of the DiaDec-study: Quality of life, health care utilisation and costs in patients with diabetes: The role of depression
Diabetes is a highly prevalent chronic disease with a substantial impact on quality of life and societal cost. Depressive disorders have been found to be more prevalent among individuals with diabetes than those without...