Methaemoglobin Content and NADH-Methaemoglobin Reductase Activity of Three Human Erythrocyte Genotypes
Journal Title: Iranian Journal of Blood and Cancer - Year 2009, Vol 2, Issue 1
Abstract
Background: To study methaemoglobin content and NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS). Materials and Methods: Studies to ascertain methaemoglobin concentration and level of NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS) were carried out in forty-three (43) healthy male participants of confirmed erythrocyte genotypes: HbAA (N=15), HbAS (N=15) and HbSS (N=13). Spectrophotometric method was used for determination of the two erythrocyte parameters. Results: Whereas methaemoglobin concentrations in the three erythrocyte genotypes was in the order: HbASp>0.05) in methaemoglobin concentration and NADH-methaemoglobin reductase activity between HbAA and HbAS erythrocytes. Conclusion: The results showed a relationship between erythrocyte NADH-methaemoglobin reductase activity and methaemoglobin concentration.
Authors and Affiliations
Paul Chidoka Chikezie
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