Methicillin Resistant Staphylococcus Aureus: A Cause of Concern
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 9
Abstract
Background: Staphylococcus aureus can cause superficial skin infections such as boils, furuncles, styes etc. to life threatening systemic illness like surgical site infections, meningitis, pneumonia, blood stream infections, osteomyelitis. Methicillin Resistant Staphylococcus aureus (MRSA) was first reported in 1961after 1 year of its clinical use. Presently MRSA is a major cause of Health care associated and community acquired infection worldwide. MRSA strains can readily develop resistance to most of the antimicrobials in clinical use. Methicillin resistance occurs mostly due to altered Penicillin binding protein (PBP2a) and mainly mediated by mecA gene. Cefoxitin resistance is a surrogate marker of mecA gene mediated Methicillin resistance. Aim: To detect the incidence of MRSA strains in our hospital and to study the antibiotic susceptibility profile of MRSA strains. Material & methods: 100 Staphylococcus aureus strains isolated from different clinical samples such as pus, blood, urine etc. were studied. Antibiotic susceptibility test was done by Kirby-Bauer disc diffusion method and Methicillin resistance was detected by using Cefoxitin 30μg disc as per CLSI Guidelines, 2016. Result: 56% Staphylococcus aureus strains were MRSA. All MRSA strains were sensitive to Vancomycin and Linezolid and resistant to Penicillin. Conclusion: Detection of MRSA strains should be done in Clinical Microbiology Laboratory for effective patients’ treatment and implementation of Infection Control measures in Health Care Setup to prevent its spread.
Authors and Affiliations
Mr. Bingu Shiv Kiran Reddy
Keywords
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