METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DOSULEPIN IN PURE AND DOSAGE FORM BY USING HPLC
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Dosulepin in its pure form as well as in tablet dosage form. Chromatography was carried out on Xterra C18 (4.6×150mm, 5µ) column using a water (100% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 230nm. The retention time of the Dosulepin was 2.1 ±0.02min. The method produce linear responses in the concentration range of 5-25µg/ml of Dosulepin . The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Dosulepin , RP-HPLC, validation.
ANALYSIS AND TREATMENT OUTCOME OF PATIENTS WITH ELECTRIC BURN IN PLASTIC SURGERY DEPARTMENT OF MAYO HOSPITAL, LAHORE
Background: When an electric current passes through the body, interferes with the function of an internal organ, or sometimes burns the tissues, it starts to fruition. From 4% to 6.5% of applications made to incineration...
DNA CLEAVAGE POTENTIAL OF 4-(PIPERIDIN-1- YLMETHYL)-2-(THIOPHEN-2-YL) QUINOLINE ANALOGUES
DNA cleavage potential of 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives, were studied on Calf-thymus DNA by agarose gel electrophoresis method. The compounds 7e and 7j have exhibited almost comp...
DESIGN AND EVALUATION OF MINI-TABLETS - PULSATILE DRUG DELIVERY SYSTEM OF RAMIPRIL
The aim of present study was to design and evaluate mini-tablets: pulsatile delivery of Ramipril based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release core mi...
PREVALENCE OF HEPATITIS B IN THE PATIENT COMING TO PATHOLOGY LABORATORY AT COMBINED MILITARY HOSPITAL (CMH) LAHORE FROM PUNJAB
Introduction; Hepatitis is a swelling or infection of the liver that makes it to stop work properly. Most of the times, viruses are the major cause of hepatitis but drug or alcohol use can also lead to hepatitis. In some...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF PHOSPHATE AND DEXTROSE CONTENT BY RP-HPLC IN CABAZITAXEL INJECTION.
A simple, accurate, precise, rugged, robust, linear and reproducible method was developed by RP-HPLC method for simultaneous estimation of phosphate and dextrose content which was used in the formulation of Cabaxitaxel i...