METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DOSULEPIN IN PURE AND DOSAGE FORM BY USING HPLC
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Dosulepin in its pure form as well as in tablet dosage form. Chromatography was carried out on Xterra C18 (4.6×150mm, 5µ) column using a water (100% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 230nm. The retention time of the Dosulepin was 2.1 ±0.02min. The method produce linear responses in the concentration range of 5-25µg/ml of Dosulepin . The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Dosulepin , RP-HPLC, validation.
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