Method Development and Validation of Neverapine by Rp-Hplc
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 7
Abstract
A simple and accurate RP-HPLC method has been developed for the estimation of Neverapine in bulk and pharmaceutical dosage forms, using C-18 column 150 x 4.6 mm i.d, 5μm particle size in isocratic mode, with mobile phase comprising of phosphate buffer (pH3) and Acetonitrile in the ratio of 40:60 v/v. The flow rate was 0.8ml/min and the detection was monitored out by UV detector at 270nm. The retention time for Neverapine was found to be 3.308min.The proposed method has permitted the quantification of Neverapine over linearity in the range of 20-60 μg/ml and its percentage recovery was found to be 101.7%.The intraday and inter day precision were found 0.06% and 0.13%, respectively.
Authors and Affiliations
Sindhu M, Ramya Tulasi G , Neeharika G , Swetha M , , Agilandeswari D , Dabhi Harshkumar D , Sajani Raju , Vineeth Chandy
Keywords
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- EP ID EP145781
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