METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD IN THE DETECTION OF EFAVIRENZ IN BULK DRUG AND TABLET FORMULATION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
A simple, highly sensitive, isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed for the determination of efavirenz in the bulk drug and tablet dosage forms. Elution medium consisting of a mixture of methanol and water in the ratio of (89:11, v/v) at flow rate 1ml/min was employed in this study. The retention time of efavirenz was found 2.58 min. The calibration curves were linear with regression coefficient (r2) of 0.9999. The proposed method was extensively validated for linearity, range, accuracy, precision and specificity. The proposed method is sensitive, specific and was successfully applied for the estimation of efavirenz in pharmaceutical formulations (bulk drug and tablet).
Authors and Affiliations
Brajendra Rajpoot
Keywords
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