Methods of hot spot identification in protein complexes
Journal Title: CHEMIK nauka-technika-rynek - Year 2015, Vol 69, Issue 6
Abstract
Energy on the surface of the protein complexes is not uniformly distributed. Some of amino acid residues – called hot spots – contribute most of the energy into interaction. H ot spots can be detected experimentally by expensive and time-consuming molecular biology techniques or by computational methods, which are able to predict hot spot residues with satisfying results. The paper presents an overview of existing methods of hot spot identification in protein complexes and a comparison of their efficiency.
Authors and Affiliations
A Tamulewicz, E Tkacz
Keywords
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