METHOTREXATE INDUCED STEVENS JOHNSON SYNDROME: A RARE CASE REPORT
Journal Title: Era's Journal of Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Methotrexate (MTX) is a folic acid antagonist with cytotoxic and immunosuppressant activity andwith potent antirheumatic action. It is commonly a first choice Disease modifying antirheumatic drug (DMARD). There were some spurious reports of Adverse Drug Reaction (ADR) by this drug. Here we report a rare occurrence of Stevens-Johnson syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) after the use of Methotrexate. Naranjo score for this adverse drug event was six, thereby making it a probable ADR. Symptomatic management of the patient was done and the offending drug was withdrawn. We are presenting this case to highlight the serious adverse reactions possible from a routinely prescribeddrug.
Authors and Affiliations
Surabhi Arora, Afroz Abidi, Fariha Fatima, Roohana Hasan, Darakhshan Rizvi, Anupriya Thadani
Keywords
Related Articles
- EP ID EP622355
- DOI 10.24041/ejmr2018.95
- Views 128
- Downloads 0
CYTOLOGY OF ADRENAL LESIONS
Cystic and solid lesions in the adrenal glands commonly present as mass lesions and have varied etiology as infectious diseases, benign eysts, adrenal neoplastic lesions and metastasis. Smaller sized and nonfunctional sm...
PULMONARY MYCETOMA DUE TO CANDIDA ALBICANS MASQUERADING BRONCHOGENIC CARCINOMA IN A PATIENT WITH TYPE -2 DIABETES MELLITUS
Fungal lesions of lung presenting as a mass are called mycetomas. Mycetoma is a conglomeration of cellular debris and mucous with finely woven fungal hyphae present in a cavity in pulmonary parenchyma or a bronchus.The m...
CYTOMEGALOVIRUS INFECTION IN PREGNANCY- A REVIEW
Primary and recurrent infections of human cytomegalovirus (HCMV) can occur during pregnancy. Both can result in congenital infection, the leading infectious cause of mental retardation, sensorineural deafness and visual...
CYTOLOGICAL GRADING OF ORAL SUBMUCOUS FIBROSIS
Oral submucous fibrosis (OSMF) is a condition that was first described in the 1950s. It is caused as a result of addiction to harmful areca nut products with or without tobacco. The rationale of using exfoliative cytolog...
CEREBEllAR CYSTIC MASS CAUSING oBSTRUCTIVE HYDRoCEPHAloUS
A 60 year old gentleman from rural background presented with history of worsening bifrontal headache, intractable vomitings and ataxic gait for last one month. All general and systemic examination was normal except neuro...