Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 5
Abstract
Methotrexate continues to be one of the most widely used systemic immunosuppressive agents in dermatology. We describe a case of low-dose methotrexate (MTX) toxicity in a patient with chronic plaque psoriasis occurring during long-standing methotrexate therapy. This case report emphasizes the fact that co-medications like NSAIDS may exacerbate MTX toxicity. This patient had a rare methotrexate-induced toxic epidermal necrolysis including cutaneous ulceration. Hence, careful consideration of concomitant medication is required to avoid drug interactions for safe long-term methotrexate treatment.
Authors and Affiliations
S. Bhuvaneshwari T. Shanmugham, C. Dinesh M. Naidu, Vinay Raghuvanshi
Keywords
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