Methotrexate Induced Toxic Epidermolysis Necrosis Stevens- Johnson Syndrome in a Child with Acute Lymphoblastic Leukemia
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 1
Abstract
Methotrexate is an antineoplastic drug commonly used in the treatment of acute lymphoblastic leukemia (ALL). There are only few studies in the literature about Stevens-Johnson syndrome (SJS), occurring in two patients with acute lymphocytic leukemia and non-Hodgkin lymphoma after receiving high doses of methotrexate and leucovorin. We report a two-year-child with ALL, developed SJS after the administration of high dose of methotrexate. Early recognition and prompt supportive treatment is crucial to reduce the treatment related morbidity and mortality.
Authors and Affiliations
Preetam Kumar Jain, Harsha Panchal, Asha s Anand, Rakesh Patil, Salil Petkar
Keywords
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