Methotrexate Induced Toxic Epidermolysis Necrosis Stevens- Johnson Syndrome in a Child with Acute Lymphoblastic Leukemia
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 1
Abstract
Methotrexate is an antineoplastic drug commonly used in the treatment of acute lymphoblastic leukemia (ALL). There are only few studies in the literature about Stevens-Johnson syndrome (SJS), occurring in two patients with acute lymphocytic leukemia and non-Hodgkin lymphoma after receiving high doses of methotrexate and leucovorin. We report a two-year-child with ALL, developed SJS after the administration of high dose of methotrexate. Early recognition and prompt supportive treatment is crucial to reduce the treatment related morbidity and mortality.
Authors and Affiliations
Preetam Kumar Jain, Harsha Panchal, Asha s Anand, Rakesh Patil, Salil Petkar
Cytodiagnosis of Fibromatosis Colli
Fibromatosis colli (FC) is a peculiar benign fibrous growth of the sternocleidomastoid that usually appears during the first few weeks of life. It is the most common cause of congenital muscular torticollis (wry neck). F...
Circulating Tumor Cells (CTCs) or Cancer Stem Cells (CSCs): The Unresolved Paradox as Drivers of Metastasis
Summary Tumor aggressiveness, relapse and metastasis are the primary causes of poor survival rates in patients with advanced stage cancer despite successful resection as well as chemotherapeutic treatment which limits th...
Summaries of Presentations at Clinical Meetings
Salivary gland tumors often pose a diagnostic challenge since they can show a striking range of morphological diversity, benign tumors have a propensity for malignant change and special stains & IHC have limited role. Ca...
Significance of Glycosylation Changes in Oral Cancer
Oral cancer is the major health burden in India. Glycosylation changes are associated with malignant transformation. Therefore, we investigated alterations in several glycoconjugates in oral cancer. Total 50 healthy cont...
Acute Myeloid Leukemia with Bombay Blood Group: A Diagnostic and Therapeutic Challenge
Bombay blood group is a very rare type of blood group with incidence of 0.0004% in the world. Individuals with rare Bombay phenotype do not express H antigen, the antigen which is present in blood group O. Bombay blood g...