Micro-RNA in Health and Disease
Journal Title: International Journal of Cardiology and Research (IJCRR) - Year 2018, Vol 5, Issue 3
Abstract
Micro-RNAs (miRNA) are functional, non-protein coding RNA molecules that are approximately 22 nucleotides in length and their transcriptions provided by intron or exon regions of the genome and non-protein coding regions of RNA genes. miRNAs inhibit translation of protein and destroy mRNA. Although approximately 2500 human miRNA types have been identified so far, quite little is known about their biological functions. In some studies, it is shown that miRNA expression levels are important for many biological processes such as cell proliferation, differentiation, apoptosis, organogenesis and metabolism. Recent studies have pointed out that miRNAs have been used as diagnosis and prognosis biomarkers in many human diseases including cancer, cardiovascular disorders, cerebrovascular disorders and metabolic disturbances.
Authors and Affiliations
Derya Demirtas
Keywords
Related Articles
- EP ID EP529652
- DOI 10.19070/2470-4563-1800020
- Views 75
- Downloads 0
Case Report of Making Diagnosis and Successful Surgical Treatment of Double Aortic Arch in Vietnam National Children’s Hospital
A 3 years old girl presented with prolonged pneumonia which was poor response to usual treatment. History: Normal past obstetric history, recurrent pneumonia since 1 year old, allergic to shrimp; no family history of a...
Alteration of Peripheral Blood T-cell Subsets in Patients with Cardiovascular Disease; Exposure to Ionizing Radiation (X-rays) and Contrast Medium
Ionizing radiation (IR) induced damage of the immune system, and exposure to IR induces subgroups of T-lymphocytes and different cell groups of immune system give different responses in individuals exposed to long-term I...
A Case Report of Systemic Sclerosis Complicated by Biventricular Heart Failure, Pulmonary Hypertension and Review of Literature
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder whose aetiology is not fully understood. Skin fibrosis and visceral organs involvement are the hallmarks, and the heart could be disproport...
“Role of D-Dimer in One Year Recurrence of Venous Thromboembolism after Completed Anticoagulation Treatment” Following A First Idiopathic Deep Vein Thrombosis
After oral anticoagulant therapy (OAT) withdrawal, the recurrence of risk is greatest in the first year and gradually diminishes, while the increased bleeding risk may offset the benefits of prolonged OAT. the benefits o...
Iatrogenic Right Sided Infective Endocarditis in Children with CHD
Background: Right sided endocarditis (IE) occurs predominantly in intravenous drug abusers, and occasionally acquired in hospital as a result of contaminated intravascular devices. The iatrogenic IE of tricuspid valve in...