Microballoons: A better approach for gastro retention
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
The purpose of this review is to accumulate the recent study on floating drug delivery system with special emphasis on microballoons as drug delivery. Microballoons are emerging as the most promising drug delivery as it overcome many limitations of conventional drug delivery system. As microballoons delivery system provides longer retention in gastric pH, hence longer is the residence time and therefore enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microsphere depends upon the preparation temperature and the surface smoothness determines the floatability and the drug release rate of the microballoons. The review includes the classification, advantages, disadvantages, method of preparation and future aspects of microballoons. Basic anatomy and physiology of stomach is also studied.
Authors and Affiliations
Rakhi Negi| Department of pharmaceutics, Division of pharmaceutical sciences, Shri guru ram rai institute of technology and science, Patelnagar Dehradun, 248001 India, Laxmi Goswami| Department of pharmaceutics, Division of pharmaceutical sciences, Shri guru ram rai institute of technology and science, Patelnagar Dehradun, 248001 India, Preeti Kothiyal| Department of Pharmacology, Division of pharmaceutical sciences, Shri guru ram rai institute of technology and science, Patelnagar Dehradun, 248001 India
Keywords
Related Articles
- EP ID EP14154
- DOI -
- Views 383
- Downloads 23
Elaeocarpus ganitrus: its beneficial antiparkinsonian effect in MPTP induced motor and non-motor impairments in mice
Aim: Elaeocarpus ganitrus (Family: Elaeocarpaceae), has shown beneficial role in the treatment of depression, convulsions and asthma. This study was undertaken to evaluate the antiparkinson effect of E.ganitrus. Materi...
Nelumbo Nucifera (Lotus): A Review on Ethanobotany, Phytochemistry and Pharmacology
Nelumbo nucifera Gaertn (Nymphaeaceae), a perennial aquatic plant, has been used as a medicinal herb in China and India. It has been recorded in the most famous medicinal book in China for more than 400 years. Different...
Evaluaton of hypoglycaemic activity of Aegel marmelos alcoholic seed extract in experimental models of hyperglycemic rats
The present study aimed to investigate the antidiabetic effect of alcoholic seed extract of Aegel marmelos in comparison with glibenclamide in in vivo using alloxan rat model.The diabetic rats were orally given glibenc...
Development of quality control parameters for the standardization of Leaves and bark of Sida acuta Burm.f
Sidha acuta Burm. f belonging to family Malvaceae is a terrestrial, erect shrub which is up to 155 cm tall. The plant is native to Mexico, Central America and Himalayan region of India but has spread throughout the tro...
Ingredients identification and quality control evaluation of phalakalyan ghrita: an ayurvedic formulation
Infertility is defined as failure to conceive within one year or more than one year of regular & unprotected coitus. It is the most sensitive and cumbersome problem which haunts every couple. Total 10-15% of world popu...