Microbiological Efficacy of Meropenem–ethylenediaminetetraacetic Acid Combination as Compared to Meropenem in a Tertiary Care Intensive Care Unit
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2019, Vol 6, Issue 11
Abstract
Background: With the global epidemic of sepsis on the rising trend and gram negative sepsis being one of the most common cause of increasing morbidity and mortality in developing nations like India, it becomes imperative to understand the role of combination antibiotics in controlling this burden. Aim and Methodology: In this study, we recognized the potential therapeutic role of Meropenem combined with EDTA against a clinical endemic isolate of multi-drug resistant extended spectrum beta-lactamases (ESBLs) producing pathogens was investigated. The E-test strips studied the antimicrobial susceptibility of the pathogens and were applied to check for in-vitro sensitivity to Meropenem and combination of Meropenem and Ca-EDTA. Result: The MIC value of Meropenem-EDTA (0.25) was less than 50% of that of Meropenem (2.45) in sensitive isolates. Conclusion: Meropenem in unification with EDTA can exhibit more potent antimicrobial activity against ESBL producing pathogens than just Meropenem or EDTA alone.
Authors and Affiliations
Charu Dutt Arora, Ajay Yadav, Mehak Batra, Maggie Ann Johnson
Keywords
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