Microcirculatory dysfunction in sepsis
Journal Title: Journal Of Pediatric Critical Care - Year 2019, Vol 6, Issue 2
Abstract
Microcirculation is a network of small blood vessels of <100 μm diameter. It includes arterioles, capillaries and venules.Its main function is to regulate the blood fl ow and distribution of fl ow to various organ systems. Dysfunction of microcirculatory systemis one of the important pathophysiologic process in sepsis evolution. In septic shock, microcirculatory dysfunction is due to endothelial dysfunction, coagulation abnormalities, tissue infl ammation, hemorheologic abnormalities, functional shunting and leukocyte-endothelium interactions. Various biomarkers are surrogate markers of measuring microcirculatory dysfunction, however, direct visualization of capillaries using video microscopic techniques is the gold standard. Therapeutic intervention for managing septic shock are mainly titrated on microcirculatory parameters and do not corelate directly with improvement at microcirculatory levels. More data is needed on practical bedside monitoring of microcirculation and titrating the therapy based on that
Authors and Affiliations
Gopala Krishnan, Arun Bansal
Keywords
Related Articles
- EP ID EP551287
- DOI 10.21304/2019.0602.00486
- Views 85
- Downloads 0
Pre Hospital Pediatric Trauma: EMS experience, Improving the Prehospital Care and Road Map for the Future
Objectives: study the Pediatric (age 0-14 years) prehospital trauma pattern for year 2015 in Telangana (TS) and Andhra Pradesh (AP). To highlight the experiences of pre hospital training and injury prevention measures in...
Post-operative Challenges in Pediatric Renal Transplant: Nephro-Intensivist Perspective
Renal transplantation is the treatment modality of choice for children with end-stage kidney disease since it decreases morbidity and mortality and improves quality of life. Children usually receive either living donor o...
Pediatric Intracranial Aneurysms and Subarachnoid Hemorrhage: Review
.
Golden Hour Management of Pediatric Polytrauma in India- Emergency Department Resuscitation
Trauma is one of the most neglected preventable diseases in India, with the 2014 National Crime Records Bureau report, detailing 63% rise in injury deaths in the past decade. Despite the worrying figures, this preventabl...
Clostridium Difficile : Epidemiology and Prevention
C. difficile is a Gram-positive anaerobic that forms part of the normal intestinal flora of the human beings.C. difficile infection (CDI) is the most common cause of hospital acquired diarrhea/antibiotic associated diarr...