Microcytic red cell morphology in Dhodia Patel Community: Is there α-thalassemia?
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 1
Abstract
Microcytic red cell indices are commonly associated with iron deficiency anemia (IDA) and β-thalassemia. If these causes are ruled out then there is a possibility of α-thalassemia [1]. α–thalassemia is caused by impaired production of α globin chains. The commonest α gene defect in the Indian population is the deletion of one or two genes. The severe and fatal form of α thalassemia, hemoglobin (Hb) Bart’s hydrops fetalis is not reported in India. Few cases of Hb H disease have been reported [2]- [5]. α–thalassemia has a widespread distribution worldwide. The literature reveals that it is mainly limited to certain tribal groups with a prevalence of 8 to 81 % [6]- [7]. Dhodia Patel is the third largest tribal community in Gujarat. Majority of them are settled in the southern part particularly in Surat and Valsad districts. Our preliminary investigation on this community suggested that healthy subjects have low values of red cell indices in absence of β-thalassemia trait. Hence it was decided to rule out IDA and α-thalassemia in this community.
Authors and Affiliations
Dr. Dipal Bhukhanvala
Keywords
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