Microemulsion Based Gel of Sulconazole Nitrate for Topical Application
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 3
Abstract
Objectives: Sulconazole is a broad spectrum antifungal agent of the imidazole class used against dermatophytes and other fungi to treat skin infections. The aim of the present work was to formulate and evaluate a microemulsion-based topical sulconazole gel. Materials and Methods: Microemulsion formulation of sulconazole nitrate was prepared by using oil, surfactant, cosurfactant and water at different ratios. This was then subjected to clarity and particle size analysis, a centrifugation test, a dilution test, and freeze thawing. Results: The zeta potential of formulation F1 was -41.3 and stable. The pH of the microemulsion formulation was within the range of pH of skin. F1 showed a higher percentage amount of drug as compared with the other formulations. The viscosity showed that F1 was optimum. The freezing and thawing results showed there was no phase separation and the formulation was stable. In vitro drug release showed that the drug release from the microemulsion of F1 was higher when compared to the other formulations. It revealed F1 had the highest drug content of 95.88±0.3% and % cumulative drug release was 88.75% release in 8 h. The in vivo skin irritation study on rats confirmed that formulation was nontoxic and nonirritant. Conclusion: The present study confirmed the safety of the formulated sulconazole loaded microemulsion gel for topical application.
Authors and Affiliations
Sumedha Prashanth PAYYAL, Narayana Charyulu ROMPICHERLA, Sandeep Divate SATHYANARAYANA, Ravi Gundadka SHRIRAM, Anoop Narayanan VADAKKEPUSHPAKATH
Keywords
Related Articles
- EP ID EP684758
- DOI 10.4274/tjps.galenos.2019.75537
- Views 192
- Downloads 0
Green Synthesis and Characterization of Copper Nanoparticles and Their Effects on Liver Function and Hematological Parameters in Mice
Objectives: The present investigation is based on the green synthesis of copper nanoparticles (CuNPs) from aqueous extract of Capparis spinosa L. fruit. Their effects on liver function and hematological parameters in mic...
Safety Assessment of Vanillic Acid: Subacute Oral Toxicity Studies in Wistar Rats
Objectives: Vanillic acid (VA) is a flavoring agent, a phenolic acid, and an intermediary by-product formed during transformation of ferulic acid to vanillin. It has been investigated for diverse pharmacological actions...
Degradation Kinetics, In Vitro Dissolution Studies, and Quantification of Praziquantel, Anchored in Emission Intensity by Spectrofluorimetry
Objectives: A simple, rapid, specific, and highly sensitive ecofriendly spectrofluorimetric method has been developed for the quantification of praziquantel. Materials and Methods: A linear relationship was found betwee...
Antibacterial, Antifungal, and Antioxidant Activity of Cleome coluteoides: An In Vitro Comparative Study Between Leaves, Stems, and Flowers
Objectives: Cleome coluteoides, which belongs to the Capparidaceae family, and has been used in folk medicine for a long time. Our research aims to measure the antioxidant, antibacterial, and antifungal activities of C....
Determination of the Genetic Relationships Among Salvia Species by RAPD and ISSR Analyses
Objectives: Salvia L. is the largest genus of the family Lamiaceae, which includes approximately 1000 species. According to recent studies, 100 Salvia species in total grow in Turkey. At the same time, 53% of them are en...