Microgenderome: An Important Variable for Developing Therapeutic Strategies?
Journal Title: Gastro - Open Journal - Year 2018, Vol 3, Issue 1
Abstract
A close association of microbiota in human health continues to emerge. Microbiota has been implicated in autoimmune disorders such as type I diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis.1 This is pointing out that early-life microbial exposure could be linked to later-life susceptibility to immune-mediated disorders. From the experimental models related to autoimmune disorders, it is known that tissue injury is prevented by alteration in microbiota or in germ-free condition. Therefore, microbial alteration can be beneficial during autoimmune disorders. However, several lines of evidence suggest the role of gender-bias, (regulation of sex-hormones by microbiota) in numerous diseases. This editorial aims to throw light on the novel, emerging triangular relationship between host microbiota, sex hormones (testosterone, progesterone and estrogen) and immune responses cumulatively termed as Microgenderome”.
Authors and Affiliations
Rohit Gundamaraju
Keywords
Related Articles
- EP ID EP555175
- DOI 10.17140/GOJ-3-e005
- Views 146
- Downloads 0
Fistulizing Crohn’s Disease Complicated by Hidden Retroperitoneal Abscess: A Case Report and Review of the Literature
Crohn’s Disease (CD) is a chronic inflammatory disorder of the intestinal tract characterized by trans-mural damage of the bowel wall often complicated by strictures, entero-visceral and perianal fistulae and abscesses....
The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments
Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced microenvi...
Capsule Endoscopy: Indications, Findings and Complications among Patients with Suspected Small Bowel Lesions
Background/Aims: Until a few years back, evaluation of small bowel pathology was unsatisfactory because of the inability to completely visualize the small bowel mucosa with the available endoscopic and radiological techn...
Effect of Chronic Proton Pump Inhibitor Use on Serum Magnesium Levels in Pediatric Patients
Hypomagnesemia has been reported in adult patients on Proton Pump Inhibitor (PPI) therapy. No studies have described the effect of this class on medications on Magnesium (Mg) levels in children. This was a retrospective...
Therapeutic and Chemopreventive Effects of Ursodeoxycholic Acid (UDCA): Potential Role in Patients with Barrett’s Esophagus
Ursodeoxycholic Acid (UDCA) is widely used for the treatment of cholestatic liver diseases. Major mechanisms of this action are protection of cholangiocytes against cytotoxicity of hydrophobic bile acids, stimulation of...