Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2017, Vol 14, Issue 3
Abstract
Objective: The aim of this study was to determine micronucleus (MN) frequencies in exfoliated cervical cells and peripheral blood lymphocytes of women with polycystic ovarian syndrome (PCOS). Materials and Methods: Fifteen patients with PCOS and 11 healthy control patients were included in the study. Cervical smears and peripheral blood were collected from all patients. Specimens were analyzed for MN frequencies and compared between the groups. In addition to MN, other nuclear anomalies connected with both genotoxicity and cytotoxicity were evaluated. Results: The MN frequencies in cervical smear and peripheral blood lymphocytes were compared in patients with PCOS and normal controls. There was no statistically significant difference between the groups regarding micronucleus frequency in peripheral blood lymphocytes (p=0.239). The mean MN scores in exfoliated cervical cells of patients with PCOS and normal controls were 1.19±0.57 and 0.74±0.34, respectively. The difference regarding micronucleus frequencies in cervical cells was statistically significant between the groups (p=0.032). Conclusion: Although study group is small, our study results support that there is an increased micronucleus frequency in cervical exfoliated cells of PCOS patients; this is a determinant of genetic hazard in the disease.
Authors and Affiliations
Rengin Karataylı, Ayşe Gül Zamani, Kazım Gezginç, Ebru Tuncez, Sema Soysal, Fikriye Karanfil, Aynur Acar, M. Selman Yıldırım
Keywords
Related Articles
- EP ID EP240922
- DOI 10.4274/tjod.10734
- Views 118
- Downloads 0
Women self-reported G-spot existence and relation with sexual function and genital perception
Objective: Aim of study to determine the existence of the G-spot from the healthy women’s point of view and to assess the relationship with sexual function and genital perception. Materials and Methods: Sexually-active...
Comparison of corifollitropin alfa and daily recombinant follicle-stimulating hormone in poor responder patients undergoing in vitro fertilization cycles
Objective The aim of this study was to compare the effect of corifollitropin alfa (CFA) and recombinant follicle-stimulating hormone (rFSH) in poor-responder patients undergoing antagonist cycles. Materials and Methods...
Could the female-to-male transgender population be donor candidates for uterus transplantation?
Objective To evaluate the eligibility of female-to-male (FtM) transgender people as donor candidates with regard to histologic, surgical, and social aspects. Materials and Methods In this prospective cohort study, 31 Ft...
Investigation of the embryotoxic and teratogenic effect of Hypericum perforatum in pregnant rats
Objective: Hypericum perforatum (HP) is a herbal product used in the treatment of depression, but its harm on the fetus has not been established. This study investigated the effects of HP according to fetal clinical, mor...
The incidence, risk factors, and mortality of preterm neonates: A prospective study from Jordan (2012-2013)
Objective: To explore the incidence of preterm delivery, maternal risk factors for having a preterm neonate, and preterm neonates’ mortality in Jordan. Materials and Methods: A cross-sectional population-based design wa...