Micronucleus Test as a Prognostic Marker in Cervical Lesions on Pap smear
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 10
Abstract
Cervical Cancer is the third most common type of cancer among women worldwide .Micronucleus is a small additional nucleus formed due to chromosomal loss of fragmentation .Their frequency appears to increase in carcinogen exposed tissue long before clinical symptoms are evident . The objective is to assess the utility of micronucleus count as a prognostic marker in cervical lesions on pap smear . In this retrospective study , we have compared the micronucleus score in the whole spectrum of cervical lesions comprising of seven groups like normal (30) , inflammatory (38), ASC-US (2), ASC-H(2), LSIL(20), HSIL(6 ), IC (2) over a period of one year , i.e from June 2015 – 2016. Histopathological correlation was done only for available cases. Two observers separately counted the number of micro nucleated cells per 500 epithelial cells in oil immersion magnification and where expressed as MN score per 500 cells . There was a stepwise gradual increase in micronucleus count from inflammatory to ASC-US to LSIL to HSIL and IC group. The mean MN scores ±SD in normal (2.57±1.38) ,inflammatory (8.21±1.26), ASC-US (10±2.83), ASC-H(13±2.83), LSIL(15.8±1.44), HSIL(20.33±1.63) and IC (23±2.83) cases of cervical lesions. The result was statically significant with p value <0.0001. MN counting can be helpful prognostic marker .This is easy , reliable ,simple, objective test which can be performed on routinely stained pap smear. Keywords: Micronucleus, Cervical smears
Authors and Affiliations
Dr. Navya. B. N, Dr. Supriya P Savant, Dr Geeta Doppa, Sathyavathi R Alva
Keywords
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