Microsatellite Plots in SOD-1 gene with Mutations and Predicted Domains reveals a possible role of Mutagenesis
Journal Title: International Journal on Computer Science and Engineering - Year 2010, Vol 2, Issue 4
Abstract
Approximately 10% of Amyotrophic lateral sclerosis/ Motor euron Disease (ALS/MND) is inherited of which up to 20% is aused by mutations, changes) in the superoxide dismutase 1 (SOD1) gene. Detailed bioinformatics study of all the known utations in the SOD1 gene revealed interesting information. The information about all the xperimentally proven mutations in the SOD1 gene was collected and analyzed using bioinformatics tools and software programs. We computationally tried to find out whether the presence of icrosatellite plot in the SOD1 gene has any significance in the generation of these mutations. Our nalysis revealed that we found 13 microsatellites out of which 7 microsatellites regions have found to be mutated and have fallen inside domain region. The mutation falling in the domain region seems to be inducting a change in the secondary structure and resulting in change or absence of rotein function. Thus indicating a positive role of icrosatellites in mutagenesis.
Authors and Affiliations
K V S R P Varma , S Ravikanth , Allam Appa Rao , E. Vamsidhar , P. Sankara Rao
Keywords
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