MICROSPHERE FORMULATION OF ESSENTIAL OIL OF ACORUS CALAMUS L. CONTROLS ASPERGILLUS NIGER GROWTH IN FINISHED LEATHER AT AN EXTENDED PERIOD OF STORAGE: FEATURING EXTRACTION, FORMULATION AND EVALUATION
Journal Title: International Journal of Pharmacognosy - Year 2016, Vol 3, Issue 7
Abstract
Plant oils have been used for a variety of purposes for many thousands of years. In particular, the anti-microbial & anti-fungal activity of plant extracts and oils have formed the basis of many applications. Since, Aspergillus niger contamination in leather and leather apparels reduces the export value considerably, demand appropriate solution. The present study emphasizes anti-Aspergillus potential of an essential oil and microsphere formulation in combating the A.niger growth in finished leather. A.niger ATCC 16888 strain was chosen for the present study. Both well diffusion and broth dilution methods are used. Mode of action and microsphere formulation and its impact on leather studied using standard protocols. Essential oil (EO) of Acoruscalamus L. exhibited appreciable Anti-Aspergillus potency compared to untreated control and standard drugs (Itraconazole &Voriconazole). The oil contains components in addition to asarone. The damage in plasma membrane and reduction in ergosterol content authenticate the antifungal action EO. The new microsphere formulation of an essential oil appreciably prevent the growth of A.niger in when tested in leather for more than 90 days compared to free oil wherein reoccurrence was evidenced within 60 days.
Authors and Affiliations
A. Gnanamani
Keywords
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