Midazolam Plasma Concentrations in Children after Anesthetic Premedication for Short Routine Cases - An Observational Study
Journal Title: Journal of Anesthesia and Surgery - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Midazolam is commonly used in pediatric patients as a sedative and anxiolytic before the induction of anesthesia. Little is known about clinically resulting plasma levels in the setting of short procedures. Aim of this study was to compare plasma levels of Midazolam at the end of intervention with the corresponding levels at the time point of anesthesia induction for short procedures. The hypothesis was that a certain percentage of patients have higher levels at the end of the procedure. Method: Twenty pediatric patients between the age of 2 and 8 years, scheduled for short (< 30 minutes) surgical procedures requiring general anesthesia were prospectively enrolled. They all received 0.5 mg/kg Midazolam rectally (maximum dose 10 mg) 30 minutes before transport to the operating room. After induction of the general anesthetic, a first blood sample was obtained, and plasma midazolam levels were determined. A second sample was collected at the end of the procedure. Results: Three patients had to be excluded from the study, because no midazolam plasma levels were detectable. Midazolam plasma levels were 0.38 ± 0.19 μmol/l in the first blood samples, and 0.2 ± 0.12 μ mol/l at the second time point. In three patients (17.6 %), the midazolam plasma level was higher at the end of the procedure than at the induction of anesthesia. Conclusion: A considerable percentage of patients displayed a higher plasma level of Midazolam at the end of the procedure (compared to the moment of anesthesia induction). This may have implications for the post-operative period.
Authors and Affiliations
Alexander Dullenkopf
Keywords
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- EP ID EP421185
- DOI 10.15436/2377-1364.17.099/1734
- Views 99
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