Mifegest and Misoprostol Combination Vs Misoprostol Alone for Termination of Second Trimester of Pregnancy
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 3
Abstract
Objective: Over the last few years, induced abortions have gained more popularity because of safe techniques and medications available. Induced abortion means will ful termination of pregnancy before the period of viability. Medical abortion in the second trimester with misoprostol alone has been shown to be affective, although in comparison with the combination of mifepristone and misoprostol, misoprostol-only protocols have required higher doses, side effects are more common and the time to complete the abortion is longer. Methods: Total of 50 eligible women were enrolled for this study and were divided in two groups of 25 each of the case group and control group. This study was conducted in Obstetrics and gynaecology department of Katihar Medical College and Hospital, Bihar. Women in the case group were given Tablet Mifepristone(200μg) orally followed by Tablet Misoprostol (200μg) vaginally after 24 hours which may be repeated every 3 hrs till 5 doses. Women in control group were given Tablet Misoprostol (200μg) vaginally which may be repeated every 3 hrs till 5 doses. Results: The combination of mifepristone with misoprostol significantly reduces the abortion to induction interval and also have fewer side effects and complications and also reduces the dose of misoprostol. Where mifepristone is not available or affordable, misoprostol alone has also been shown to be effective, although a higher total dose is needed and efficacy is lower than for the combined regimen. Therefore, whenever possible, the combined regimen should be used. Conclusion: Mifepristone followed by misoprostol was more effective and has a shorter Induction abortion interval and fewer side effects
Authors and Affiliations
Rashmi Verma
Keywords
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