Mifepristone for cervical ripening and induction of labour
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2018, Vol 5, Issue 1
Abstract
Objective: To study the efficacy of oral mifepristone in pre induction cervical ripening and induction of labour in term pregnancy. Materials and Methods: This is a single blind randomised control trial. 200 women with term pregnancy and bishop score < 6 were recruited and randomly allocated into two groups. Women who received tablet mifepristone 400 mg were assigned to study group (n=100) and who received placebo orally were assigned to control group (n=100). At the end of 48 hours, change in the bishop was assessed and accordingly induction/ augmentation of labour was done. Analysis regarding safety and efficacy of the drug was done with regards to maternal and perinatal outcome. Results: Among 200 women, 100 received mifepristone and 100 received placebo. In mifepristone group, 75% patients entered into labour within 48 hours of induction as compared to 48% in placebo group. The mean time interval between induction to start of labour pains was 28 hours 54 min in group A and 42 hours 18 min in group B. This difference was statistically significant. (p=0.000). In the study group 70% patients delivered within 48 hours of treatment as compared to 38% patients in control group. Mean induction delivery interval was 35 hours 38 min in study group and 49 hours 52 min in control group (p=0.000). There were fewer caesareans in the mifepristone treated group (10%) than placebo group (20%) particularly for failed induction (2 versus 6) and non progress of labour (2 versus 5). There was no statistically significant different in perinatal outcome between two groups. Conclusion: Mifepristone has modest affect on cervical repining when given 48 hour prior to labour induction and appears to reduce need for further induction compared to placebo. Mifepristone is a simple and effective method of inducing labour in women with term pregnancy and unripe cervix. The use of Mifepristone provides an interesting new alternative to classic uterotonic agents when induction of labour is necessary.
Authors and Affiliations
Deepika. N, Arun Kumar
Keywords
Related Articles
- EP ID EP472885
- DOI 10.18231/2394-2754.2018.0004
- Views 78
- Downloads 0
The effect of tranexamic acid on blood loss after vaginal delivery
Objectives To find out the effect of tranexamic acid on blood loss after vaginal deliveryMaterials and Methods In this observational study 100 women with a singleton pregnancy were allocated to receive one gram intraveno...
Saline infusion sonography (SIS) as a diagnostic tool for various endometrial pathologies and its comparison with hysteroscopy and histopathology
Aims and Objective To assess the role of saline infusion sonography SIS in diagnosing endometrial pathologies in young peri and postmenopausal women and its comparison with hysteroscopy and histopathologyMaterials and Me...
Role of who modified partograph in management of spontaneous labour in primigravidas
Introduction Pregnancy and child birth though considered as physiological process can become lethal for any woman Childbirth was considered as rebirth to a woman in olden era The atmost duty of an Obstetrician is to iden...
Role of tranexamic acid in reducing maternal mortality and need of surgical intervention in women with clinically diagnosed postpartum hemorrhage
Postpartum hemorrhage accounts for > 25% of deaths, an effective treatment for postpartum hemorrhage (PPH) would contribute importantly to the Millennium Development Goal of decreasing maternal mortality. Objective: To o...
Efficacy of emergency internal iliac artery ligation in controlling post-partum hemorrhage
Management of severe pelvic hemorrhage remains a major challenge in obstetrics as well as gynecology. Bilateral internal iliac artery ligation (BIAL) has been tried in this condition with varying success. The purpose of...