Mifepristone for cervical ripening and induction of labour

Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2018, Vol 5, Issue 1

Abstract

Objective: To study the efficacy of oral mifepristone in pre induction cervical ripening and induction of labour in term pregnancy. Materials and Methods: This is a single blind randomised control trial. 200 women with term pregnancy and bishop score < 6 were recruited and randomly allocated into two groups. Women who received tablet mifepristone 400 mg were assigned to study group (n=100) and who received placebo orally were assigned to control group (n=100). At the end of 48 hours, change in the bishop was assessed and accordingly induction/ augmentation of labour was done. Analysis regarding safety and efficacy of the drug was done with regards to maternal and perinatal outcome. Results: Among 200 women, 100 received mifepristone and 100 received placebo. In mifepristone group, 75% patients entered into labour within 48 hours of induction as compared to 48% in placebo group. The mean time interval between induction to start of labour pains was 28 hours 54 min in group A and 42 hours 18 min in group B. This difference was statistically significant. (p=0.000). In the study group 70% patients delivered within 48 hours of treatment as compared to 38% patients in control group. Mean induction delivery interval was 35 hours 38 min in study group and 49 hours 52 min in control group (p=0.000). There were fewer caesareans in the mifepristone treated group (10%) than placebo group (20%) particularly for failed induction (2 versus 6) and non progress of labour (2 versus 5). There was no statistically significant different in perinatal outcome between two groups. Conclusion: Mifepristone has modest affect on cervical repining when given 48 hour prior to labour induction and appears to reduce need for further induction compared to placebo. Mifepristone is a simple and effective method of inducing labour in women with term pregnancy and unripe cervix. The use of Mifepristone provides an interesting new alternative to classic uterotonic agents when induction of labour is necessary.

Authors and Affiliations

Deepika. N, Arun Kumar

Keywords

Related Articles

Successful pregnancy outcome in a case of Cushing�s disease

Cushing’s Syndrome is difficult to diagnose during pregnancy. It could be mistaken for preeclampsia or gestational diabetes. Early recognition and treatment ensures smooth course of pregnancy and improves maternal and fe...

Correlation of serum thyroid stimulating hormone and prolactin in female infertility � a case control study

Background: Thyroid dysfunction and high prolactin levels can affect fertility due to anovulatory cycles, luteal phase defects and sex hormone imbalance. The study was designed to evaluate the status of Thyroid stimulati...

Role of tranexamic acid in reducing maternal mortality and need of surgical intervention in women with clinically diagnosed postpartum hemorrhage

Postpartum hemorrhage accounts for > 25% of deaths, an effective treatment for postpartum hemorrhage (PPH) would contribute importantly to the Millennium Development Goal of decreasing maternal mortality. Objective: To o...

Maternal and perinatal outcome of eclampsia in SDM Medical College Department of Obstetrics and Gynaecology- a 5 years retrospective study

Background: A 5 year retrospective study is carried out in the SDM College of Medical Science and Hospital from 2011 to 2015 to determine the factors influencing the fetal and maternal outcome. The purpose of the study i...

Asherman�s Syndrome: Commutable to pregnancy

Asherman's Syndrome is an acquired uterine condition, characterized by the formation of adhesions or scar tissue inside the uterus and/or the cervix. Patients usually present with infertility, recurrent pregnancy loss, m...

Download PDF file
  • EP ID EP472885
  • DOI 10.18231/2394-2754.2018.0004
  • Views 76
  • Downloads 0

How To Cite

Deepika. N, Arun Kumar (2018). Mifepristone for cervical ripening and induction of labour. Indian Journal of Obstetrics and Gynecology Research, 5(1), 15-19. https://europub.co.uk/articles/-A-472885