Mifepristone in Obstetrics and Gynaecology
Journal Title: The New Indian Journal of OBGYN - Year 2018, Vol 4, Issue 2
Abstract
Mifepristone acts by antagonising the biological action of progesterone acting as competitive receptor antagonist. Medical abortion with mifepristone and prostaglandin is an effective method. Continuous administration of mifepristone in a dose of 2mg/day for 30 days inhibits ovulation and delays menstruation. It has also been used in a dose of 600 mg as post-coital contraception within 72 hours. It has marked effect on cervical dilatation and myometrial contractility and therefore justifies its future trial for use in induction of labour. It can be used for the treatment of ectopic pregnancy and endometriosis but further verification is needed by randomized controlled trials. Mifepristone reduces BCL-2, decreases EGF expression in uterine fibroid cells and increases TNF and thereby reducing fibroid size and volume. Recent cochrane study revealed that mifepristone reduces heavy menstrual bleeding and improved fibroid specific quality of life but does not reduce fibroid volume significantly and further studies are required for recommendation for treatment.
Authors and Affiliations
Saswati Sanyal Choudhury
Keywords
Related Articles
- EP ID EP453419
- DOI 10.21276/obgyn.2018.4.2.3
- Views 132
- Downloads 0
A clinical study of septic abortions in a tertiary care referral centre in rural India - Still a neglected scenario which can be a preventable catastrophe
Objectives: The aim of the present study was to assess the magnitude of septic abortion in a tertiary care referral hospital and study their complications. Methods: It was a retrospective study done on patients who were...
Emergence of Zika virus in India: Implications for pregnant women and obstetrician
With the emergence of first case of Zika virus infection in India, it is very important to know the consequences of this infection on the pregnant women and her foetus. At the same time the obstetrician and her treating...
A serological study of cytomegalovirus infection in patients presenting with bad obstetric history attending Assam Medical College and Hospital
Objective: To study the seroprevalence of Cytomegalovirus (CMV) infection in patients with bad obstetrics history (BOH). Methods: This study was carried out for a period of one year, from June 2012 to May 2013. A total o...
Epidemiology of maternal death in a tertiary care centre
Objectives: To estimate the maternal mortality rate and to study the related factors responsible for the maternal deaths during the period from 2011 to 2016. Materials and methods: The present study was a retrospective r...
Pregnancy outcome in women with congenital heart disease in a tertiary care centre
Objective: To find out prevalence of congenital heart disease in pregnant women and its cardiac, obstetric and neonatal outcome. Methodology: A prospective study was conducted on 74 mothers who had congenital heart disea...