Mild Hyperhomocysteinemia, Decreased Vitamins B6, B12 and Folic Acid in Children with Sickle Cell Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 10, Issue 5
Abstract
Background: Hyperhomocysteinemia has been identified as a risk factor for stroke and other vascular diseases in the general population, its role in sickle cell disease (SCD) has not been investigated in children with SCD in Nigeria. Aim: This study was designed to evaluate plasma homocysteine, B-vitamins, folate and lipid profile in sickle cell disease (SCD) HbSS children in Nigeria. Methods: Fifty (50) SCD children (12.04±4.17 years) consisting of 30 females and 20 males were selected from Sickle club center Abeokuta. Fifty non SCD (HbAA) children (12.62±4.28 years) consisting of 25 males and 25 females were included as controls. Anthropometric indices and plasma homocysteine, B12, B6, folic acid, lipids and lipoproteins were determined using standard procedures. Results: The results showed significant decreases in body weight (29.84±10.68 kg) and height (1.37±0.16 m), (p<0.045) in all SCD patients. Plasma total homocysteine (tHcy) (6.40±3.37 µmol/L) was significantly increased (p< 0.05), whereas plasma vitamins B6 (28.81±12.44 nmol/), B12 (184.16±35.13 pmol/L), folic acid (46.73±9.93 µmol/L), total cholesterol (102.42±28.62 mg/dl), low density lipoprotein cholesterol (24.45±5.25 mg/dl) (p< 0.01) and triglyceride (71.98±22.61 mg/dl) (p<0.04) were markedly decreased compared with the control values. Plasma high density lipoprotein cholesterol was however not significantly different from the control value. Plasma tHcy) did not correlate with any of the measured parameters. Conclusion: Increased plasma total homocysteine level and reduced B vitamins as well as lipids profile obtained in this study are prominent features of sickle cell disease in this environment.
Authors and Affiliations
M. O. Ebesunun, I. O. Nnaji, K. J. Adetunji
Keywords
Related Articles
- EP ID EP348212
- DOI 10.9734/BJMMR/2015/19623
- Views 72
- Downloads 0
A Survey on the Quality of Life in Patients with Bronchial Asthma in an Outpatient Clinic in Malaysia
Introduction: Bronchial asthma is one of the common diseases encountered by the physicians which leads to morbidity and mortality. Therefore it is important to know the quality of life in these patients. So that necessar...
Blood Parameters and Spleen Histology Following Chronic Consumption of Ethanolic Extract of Costus afer Stem and Juice on Albino Wistar Rats
Aim: Costus afer is a medicinal plant used as a therapy for diabetes and hypertension. This study investigated the effect of crude ethanolic extract of Costus afer (Monkey sugar cane) stem and its juice on the histology...
Rare Case of Multiple Compound Odontomas with Dens Invaginatus Associated with Impacted Primary and Unerupted Permanent Maxillary Central Incisor – A Case Report
Aims: An Odontoma is usually found in the surrounding area of the unerupted permanent tooth bud and rarely adjacent to the primary central incisor. Histopathological examination of the Odontoma revealed presence of surfa...
Bedside Focused Ultrasound in Necrotizing Fasciitis: The “Black-hole Sign”
Introduction: Necrotizing fasciitis (NF) is a life-threatening infection of soft tissues, requiring prompt diagnosis and an aggressive management. The role of ultrasonography (US) in emergency setting for early diagnosi...
Adeno-Hypophyseal Consequence of Uterine Fibroid and the Effects of Ginger Extract on the Monosodium Glutamate-Induced Tumor
Background: Uterine fibroids, also referred to as uterine myomas, leiomyomas, myomatas, or simply fibroid are benign soft-tissue tumors that arise from uterine smooth muscle tissue (myometrium). They have been described...