MIMOSINE - A NOVEL SUBSTANCE AND EVALUATE THE LIPID PEROXIDATION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: The mimosine is a novel substance extracted and purified from Mimosa pudica. The present study is to evaluate lipid peroxidation (LPO). Methods: The sox halation is used to differentiate extracts. Mimosine is purified by gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS). The present study was conducted to evaluate the hepatoprotective activity of ethanol extract of M. pudica against alcohol-induced albino rats. This was evident from significant of M. pudica on LPO and antioxidants liver of rats. Results: By GC–MS and LC–MS, the mimosine is purified and it shows the highest peak. The phytochemical analysis of M. pudica and the activity of the enzyme antioxidants such as superoxide dismutase is 176.83 g and peroxidase is 0.989 g, were found to be present in the plant extract of M. pudica. In rat treated with toxic dose of alcohol, a significant increase in serum and liver were observed. Simultaneous oral administration of the aqueous extract of M. pudica reduced the lactate dehydrogenase (LDH) activity to a significant extent compared to control. LDH, a cytosolic liver marker enzyme, is a regulator of many biochemical reactions in the body tissues and the fluid. Conclusion: The result obtained in our work, existence of bioactive substance proves that it is mainly used as a traditional medicine. The phytochemical analysis indicated the presence of alkaloids, steroids, terpenoids, tannin, phenolic, saponins, proteins, and amino acids. The liver showed that the induction of alcohol causes hepatic necrosis and injury, but it is cured by M. pudica.
Authors and Affiliations
DHANYA K G, THANGAVEL M
Keywords
Related Articles
- EP ID EP603825
- DOI 10.22159/ajpcr.2019.v12i3.22812
- Views 113
- Downloads 0
INFLUENCE OF GENDER AND OBESITY ON ANALGESIC MODULATION OF TRAMADOL IN RATS
Objective: The objective of this study was to investigate the influence of gender and obesity on analgesic modulation of tramadol in Wistar rats.Methods: This study was carried out in two sets of experiments. In Set I ex...
MONITORING AND ANALYSIS OF ADVERSE DRUG REACTIONS IN A PRIVATE TERTIARY CARE TEACHING HOSPITAL
 Objectives: To monitor and analyse the suspected adverse drug reactions (ADRs) reported at Vydehi Hospital, Bengaluru.Methods: A prospective observational study was conducted between July 2011 and August 2012. Suspecte...
SOLID DISPERSIONS: RESUSCITATING ORAL DELIVERY OF HYDROPHOBIC DRUGS
Objective: This review article explores solid dispersions (SDs) as one of the suitable approaches to formulate poorly water-soluble drugs. The objective of this review on SD techniques is to explore their utility as a fe...
FALSE DIAGNOSIS IS A THREAT - A CASE STUDY
Objective: To explore the possibility of false diagnosis and threat to health. Methods: In the present study, a case history of 23-year–old lactating woman&nbs...
PARTIAL CHARACTERIZATION AND ANTIMICROBIAL PROPERTY OF SMALL PEPTIDES ISOLATED FROM THE FLOWERS OF MILLINGTONIA HORTENSIS
Objective: The flowers of Millingtonia hortensis were initially screened for the presence of Cu (II) ninhydrin-positive compounds. Purification and characterization of small alpha peptides from the flowers of M. hortensi...