Abstract

Anti-TNF-α medications have become a mainstay of treatment of moderate to severe symptoms of diseases including inflammatory bowel disease, ankylosing spondylitis, psoriasis and arthritis. There are many well-known adverse effects of anti-TNF-α biologic agents, the most common of which are hypersensitivity-like symptoms of erythema, pruritus, nausea, vomiting and airway compromise. Rarer, more serious complications of anti-TNF-α biologic agents such as lymphoma have also been reported. To date, there have been a few cases in medical literature of nephrotoxic reactions following commencement of anti-TNF-α therapy. Our case report details the first reported case of minimal change nephrotic syndrome associated with the use of anti-TNF-α medications followed by the development of Hodgkin's lymphoma in a pediatric patient.

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