Minimally Differentiated Acute Myeloid Leukemia (FAB M0) in a Child with Down Syndrome: A Case Report
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Children with Down syndrome (DS) have 10-100 fold increased risk of leukemia. >90% cases present with morphology and immunophenotype characteristic of acute megakaryoblastic leukemia (FAB M7). Other AML FAB described in DS include M0, M1/2 and M6. In addition, 10% of DS neonates manifest Transient Abnormal Myelopoiesis (TAM) which resolves spontaneously within 3 months. TAM is difficult to distinguish from AML and immunophenotyping along with the clinical course can give clues to final diagnosis. We present a case of DS presenting as AML M0 and experiencing a fatal outcome.
Authors and Affiliations
Neha Garg, Dr. Surabhi, Mrinalini Kotru
Keywords
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- EP ID EP535404
- DOI 10.21276/ijmrp.2018.4.4.050
- Views 71
- Downloads 0
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