Minocycline trial in japanese encephalitis: a double blind, randomized placebo study
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 5
Abstract
Objective: To evaluate the effect of minocycline in Japanese Encephalitis (JE ) patient on reduction in mortality, neurological deficit and behavioral outcome. Design: Double blind randomized placebo control trial. Setting: Tertiary level hospital. Inclusion criteria: Only JE patients who were IgM positive for JE Virus (JEV) in cerebrospinal fluid and/or serum were included. Exclusion criteria: Those clinically suspected JE patients who were IgM negative for JE Virus (JEV) in cerebrospinal fluid and serum were excluded. Patients were selected randomly. Intervention: A total of 44 patients of JE of the age range between 1-13yr were divided equally in two groups A and B. Group A received drug under study, that is minocycline, and Group B received placebo. Outcome measures: The present study was designed to: compare the clinical course during hospitalization and after discharge in terms of duration of symptoms, death and disability at the time of discharge, outcome of the intervention on clinical recovery, behavioral problems and neurological deficit after 12 month of follow up. Results: Duration of fever, unconsciousness and total duration of hospital stay were significantly reduced in Group A (minocycline) patients. Conclusion: Minocycline has significant beneficial effect in JE patients in duration of major symptoms and duration of hospital stay. However, the mortality rate and prevalence of neurological deficits and behavioral problems on a 12 months follow up remain unchanged.
Authors and Affiliations
Abhishek Kumar Singh, Anita Mehta, K P Kushwaha, Ashok Kumar Pandey, Mahima Mittal, Bhoopendra Sharma, Jayesh Pandey
Keywords
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- EP ID EP225019
- DOI 10.17511
- Views 154
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