MISOPROSTOL FOR THE PREVENTION OF POST-PARTUM HAEMORRHAGE: A RANDOMIZED CONTROLLED TRIAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 30
Abstract
BACKGROUND The leading causes of pregnancy-related deaths are haemorrhage, embolism and hypertensive disorders of pregnancy. Postpartum haemorrhage is a major preventable cause of maternal morbidity and mortality in developing countries.1 Uterine atony is the main cause of PPH. Therefore, to reduce PPH, we have to address the role of uterotonics. In this context, addition of misoprostol along with WHO recommended 10 units oxytocin in active management of third stage of labour may play an important role. This study was conducted with the aim of comparing the efficacy of Misoprostol plus oxytocin versus oxytocin only for the prevention of post-partum haemorrhage. METHODS This randomized controlled trial was performed at R. G. Kar Medical College and Hospital to compare the efficacy of misoprostol along with oxytocin for the prevention of post-partum haemorrhage (PPH) with oxytocin only in the third stage of labour to prevent of postpartum haemorrhage. 600 women without risk of PPH were randomly allocated to receive either 600 mcg orally, misoprostol along with 10 units of oxytocin intramuscularly (Group I) or 10 units of oxytocin intramuscularly (Group II) within 1 minute of delivery, 300 in each group. The efficacy and the safety of these two drugs were analysed on the basis of percentages fall in haemoglobin (Hb) from pre delivery to 48 completed hours after delivery and also need for blood transfusion. RESULTS 600 mcg orally misoprostol along with 10 unit of oxytocin intramuscularly is better than 10 units of oxytocin intramuscularly to control PPH with minimal side effects. CONCLUSIONS 600 mcg oral misoprostol along with 10 units of oxytocin intramuscularly may be recommended in place of 10 units of oxytocin intramuscularly to control PPH.
Authors and Affiliations
Abhijit Rakshit, Madhumita De, Projit Roy
Keywords
Related Articles
- EP ID EP670355
- DOI 10.18410/jebmh/2019/407
- Views 84
- Downloads 0
A CROSS SECTIONAL STUDY OF NEUROPATHY IN PATIENTS ON ART WITH COMPARISON TO PATIENTS ON BOTH ART WITH ATT
BACKGROUND It is estimated that there are 35.5 million PLHA worldwide and 1.6 million have received ART. ART is freely available in designated ART centers. The main challenge in prescribing HAART along with ATT is ADRs a...
RYLE’S TUBE INDUCED SUPRA-GLOTTIC EDEMA AND STRIDOR
Ryle’s tube insertion is a simple routine clinical procedure usually without any complications. Minor complications like injury to nasal or oral cavity and epistaxis may occur with the insertion of Ryle’s tube. However i...
GROSS ANATOMY AND BLOOD SUPPLY OF SMALL INTESTINE IN FOETUSES
AIM OF STUDY: To develop charts of length and width of small intestine, origin, length and branching pattern of celiac trunk and Superior mesenteric artery. This will help us to know any congenital anomaly in the small i...
A STUDY ON CARDIOVASCULAR AUTONOMIC FUNCTIONS IN CAREGIVERS OF STROKE PATIENTS
BACKGROUND Stroke (cerebrovascular accident) is an important cause of disability in countries like India and longterm care of these bedridden patients is usually undertaken by the family members. A caregiver is a person...
CLINICAL STUDY OF ASSOCIATION OF BMI WITH RETINOPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
BACKGROUND Diabetes mellitus is known from the earliest times and its principal clinical symptoms were clearly recognised by the Hindus, Greeks and Arabians. Diabetes is a chronic illness characterised by either relative...