Mitochondrial Translocase Expression Profile in Renal Cancer
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 6
Abstract
<strong>Background: </strong>mitochondrial appropriate function depends on ideal mitochondrial translocation machinery, of which translocase of outer mitochondrial membrane (TOMM) have a vital role in normal functioning cell. Any disturbance in the translocation machinery leads to either tumorigenesis or apoptosis. <strong>Aim of the work</strong>: This study aimed to investigate the expression of TOMM34 in renal cell carcinoma (RCC). TOMM34 expression was assessed in 42 samples of RCC patients using immunohistochemistry technique. <strong>Results: </strong>immunohistochemical staining revealed significant accumulation of TOMM34 protein in RCC cases compared to their corresponding non-cancerous renal tissues. TOMM34 protein expression was significantly associated with age and gender categories in contrast to the other clinicopathological features. <strong>Conclusion</strong>: according to protein expression level this study demonstrated that TOMM34 is a marker of poor outcome in RCC.
Authors and Affiliations
Eman Helal
Keywords
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- DOI 10.12816/0044346
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