Mitomycin-C Use and Complications in Ophthalmology
Journal Title: International Journal of Clinical Anesthesia and Research - Year 2017, Vol 1, Issue 1
Abstract
Mitomycin-C, first found its way into ophthalmic use in 1969, in Japan, where recurrent pterygia were successfully treated with the drug which is an antineoplastic / antibiotic agent isolated from the soil bacterium Streptomyces caespitosus [1]. It is an anti-metabolite with anti-proliferative effect on cells showing the highest rate of mitosis by inhibiting DNA synthesis and interferes with RNA transcription and protein synthesis [2].
Authors and Affiliations
Tongabay Cumurcu
Keywords
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