MMP-9 and the Catheter Ablation Tactics Choice
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Objectives – The purpose of this study was to determine the relationship between matrix metalloproteinase 9 and atrial fibrillation recurrence after catheter ablation. Background–Matrix metalloproteinase – 9 (MMP-9)is involved in extracellular matrix remodeling whichis considered to be a marker of extracellular collagen degradation. Methods– An enzyme-linked immunosorbent assay prior to a radiofrequency catheter ablation (RFA) procedure was used for measuring the serum level of MMP-9 in 210 patients: 80 patients without history of atrial fibrillation (AF) and 80 patients with idiopathic AF (paroxysmal AF – 30, persistent AF – 32, long-standing AF – 35 and permanent AF – 33). Their relationship with intraoperative efficacy and recurrence of AF was evaluated throughout the entire observation period. Results: The observation period was 22.2 ± 7.9 months. MMP-9 level was higher in the groups of patients with AF than in the control group: 170.5 ± 24.2, 202.7±28.4, 230.8 ± 21.1 and 252.6 ± 24.5 ng/ml for paroxysmal, persistent, long-standing and permanent forms of AF. In the control group, MMP-9 level was 75.9 ± 14.6 ng/ml. MMP-9 level increased with the progression of AF (p<0.05). A multifactor analysis showed that MMP-9 level, history of atrial fibrillation and left atrial volume were independent predictors of sinus rhythm recovery and recurrence of AF. Conclusion –An increase in MMP-9 level in patients with AF has been shown. An increase in MMP-9 levels was observed as AF progressed. MMP-9 is an independent predictor of arrhythmia recurrence after RFA.
Authors and Affiliations
Oleksiy V. Goriachyi MD, Anatoliy I. Gozhenko Prof.
Keywords
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- EP ID EP572319
- DOI 10.9790/0853-1804046169.
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