Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 4
Abstract
The online version of this article (doi:10.1208/s12248-015-9750-8) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Nageshwar R. Budha, Maya Leabman, Jin Y. Jin, D. Russell Wada, Amos Baruch, Kun Peng, Whittemore G. Tingley, John D. Davis
Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity—An Overview for Applied Toxicology
The online version of this article (doi:10.1208/s12248-011-9301-x) contains supplementary material, which is available to authorized users.
Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence
The online version of this article (doi:10.1208/s12248-016-9870-9) contains supplementary material, which is available to authorized users.
Antitumor Activity of Gemcitabine Can Be Potentiated in Pancreatic Cancer through Modulation of TLR4/NF-κB signaling by 6-Shogaol
The online version of this article (doi:10.1208/s12248-013-9558-3) contains supplementary material, which is available to authorized users.
Use of Different Parameters and Equations for Calculation of IC50 Values in Efflux Assays: Potential Sources of Variability in IC50 Determination
The online version of this article (doi:10.1208/s12248-013-9554-7) contains supplementary material, which is available to authorized users.
Effect of PEG Surface Conformation on Anticancer Activity and Blood Circulation of Nanoemulsions Loaded with Tocotrienol-Rich Fraction of Palm Oil
Tocotrienol-rich fraction of palm oil, which contains the isomers of vitamin E, was shown to possess potent anticancer activity against mammary adenocarcinoma cell lines. Its clinical use, however, is limited by poor ora...