Modern approach to pediatric asthma
Journal Title: Moldovan Medical Journal - Year 2018, Vol 61, Issue 2
Abstract
Background: The article reviews aims to promote the communication between scientists engaged in basic research and clinicians working with children, in order to better understand the mechanism and work together towards an optimal management of this prominent pediatric condition. We reviewed the recent advancements in regards to pediatric asthma related to pathogenesis, diagnostic criteria and differential diagnosis, and peer-reviewed evidence for efficiency of pharmacological and non- pharmacological/alternative/adjuvant treatment; we also emphasize the importance of education of all parties involved in care, outpatient management, age-appropriate involvement of children in their own care, and asthma prevention measures in children. Clinically asthma is characterized by recurrent episodes of wheezing, dyspnea, and cough; at the pathophysiological level the airway wall thickness is increased and involves both smooth muscle and collagen tissue, the mucous glands and mucus production are increased, and the vascularity of the airways is increased, all leading to chronic inflammatory remodeling of the airways and resulting in reduction of lung function. Conclusions: Asthma among children has been on the rise for decades. With an estimated prevalence of 10-30%, asthma is the most prevalent chronic disease of pediatric population worldwide and one with a large health care burden. The approach to diagnosis and treatment of asthma in children is distinct from adults; so is the management, prevention and the education of parties involved in care. Recently there has been a significant progress in mechanistic understanding of asthma; further, asthma management in children is becoming a top priority.
Authors and Affiliations
Svetlana Sciuca, Natalia Antonovici, Angela Dolganiuc
Keywords
Related Articles
- EP ID EP482294
- DOI 10.5281/zenodo.1299035
- Views 177
- Downloads 0
Anti-inflammatory activity of Adenoprosin in nonbacterial prostatitis
Background: The treatment of chronic nonbacterial prostatitis remains an unexplained urology problem. Adenoprosin is a new entomological product containing lipoprotein extract of Lepidopteran insect species. Laboratory s...
Anatomic peculiarities of cervix uteri ligaments in pre- and postnatal human ontogenesis
Background: Uterus and uterine cervix ligament concept is a decisive factor for female pelvis surgery and for fundamental mechanisms of urogenital dysfunction ascertainment. According to publications, there are contradic...
Oxidative stress and inflammation biomarkers in pulmonary tuberculosis
Background: Tuberculosis outcome and clinical features of the infection are influenced by the degree of the multiplication of mycobacterias, host’s defense mechanisms and the organism’s capacity to fight through the anti...
Correlation between spinal nerves, anterolateral abdominal wall muscle tone and inguinal hernia
Background: The complete diagnosis of pathomorphological disorders in case of diseases of the spine determines the choice of effective treatment, pathogenetically argued in various diseases which, according to modern cla...
Predictive factors associated to low tuberculosis treatment outcome: cross sectional study
Background: The standard treatment for new case of drug-susceptible tuberculosis according to WHO recommendations in the Republic of Moldova has been performed since 2000 and must achieve a treatment success rate of at l...