Modern approach to the diagnosis of cardiovascular disorders newborns at perinatal risk in the neonatal period
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 1
Abstract
In order to improve and systematize the approach to the diagnosis of cardiovascular disorders in newborns by comprehensive assessment of Doppler echocardiography parameters, biochemical markers (lactate dehydrogenase (LDH), γ-glutamyltransferase (GGT) levels) and polymorphic variants of C786T in the endothelial nitric oxide synthase (eNOS) gene, T58C in mitochondrial superoxide dismutase gene (MnSOD2) and Ser49Gly in β1-adrenoceptor gene (ADRB1), 133 newborns were examined, 73 of them were at perinatal risk (group 1) and 60 — healthy full-term neonates (group 2). According to the results of the study, biventricular dysfunction is detected in 19.1 % of children in group І, among them 4 (5.5 %) children were found to have systolic-diastolic and 10 (13.6 %) newborns — diastolic dysfunction of the heart ventricles. Besides, 12 (20.0 %) pre-term infants and 4 (30.7 %) newborns with intrauterine growth retardation had hypokinetic type of central hemodynamics accompanied by elevated levels of LDH and GGT in serum and changes in the diastolic filling of the heart ventricles. The study showed an association between SS genotype of eNOS gene polymorphism and contractile capacity of the left ventricular myocardium, the integral function of the left ventricle according to Tei index in pre-term infants from the perinatal risk group, carriers of C allele by MnSOD2 gene polymorphism and pulmonary hypertension in the neonatal period. The presence of GG genotype of ADRB1 gene polymorphism can be considered as a predictor for the development of hypokinetic regimen of central hemodynamics.
Authors and Affiliations
M. O. Gonchar, A. D. Boichenko
Keywords
Related Articles
- EP ID EP280727
- DOI 10.22141/2224-0551.13.1.2018.127072
- Views 79
- Downloads 0
Intestinal Colic in Infants
The paper presents the most common functional disorder of the gastrointestinal tract in infants — intestinal colic. The causes of this syndrome, the pathogenetic mechanisms of its development and methods of prevention an...
Ways of Improvement of Treatment Efficacy of Bronchopulmonary Diseases in Infants
The use of vitamin mineral treatment complexes for vitamin deficiency correction in infants with pneumonia is still being discussed. The paper presents the analysis of advisability of Pikovit sirupus use in children with...
Receptor Basis for Mechanisms of Development of Local Inflammation of the Gastric Mucosa in Children with Helicobacter pylori Infection
The article presents data on the role of factors for innate immunity recognition in the development of local inflammation of the gastric mucosa in children with Helicobacter pylori (Н.pylori) infection. The aim of the st...
Ways to Optimize Therapy of Prolonged Conjugation Jaundice in Infants
The article is devoted to the optimization of the treatment of prolonged conjugation jaundice. Inclusion of ursodeoxycholic acid in the treatment of neonatal prolonged conjugation jaundice in a dose of 15–20 mg/kg of bod...
Cytomegalovirus Infection in Children: Treatment Approaches in Different Course of Infection
Diseases caused by cytomegalovirus infection largely determine the health status of children that is due to the spread of infection and often due to its severity. The paper presents approaches to rational and effective t...