Modified Approaches for Colon Specific Drug Delivery System: A Review
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 3
Abstract
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review mainly describes the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules. Oral administration of different dosage forms is the most commonly used method due to flexibility in design of dosage form and high patient acceptance, but the gastrointestinal tract presents several formidable barriers to drug delivery. In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption in to the blood), negligible brush boarder membrane activity, and much less pancreatic enzymatic activity as compared with the small intestine. Colon-specific drug delivery has gained increased importance not just for the delivery of the drugs for treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. In the recent times, the colon specific delivery systems are also gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein and peptide drugs. This review updated the research on different approaches formulation and evaluation of colon-specific drug delivery.
Authors and Affiliations
Ritesh Kumar| College of Pharmacy, Agra, Uttar Pradesh, India, Amrish Chandra| Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India, Pawan Kumar Gautam| Department of Pharmacy, S. N. Medical College, Agra, Uttar Pradesh, India
Keywords
Related Articles
- EP ID EP13648
- DOI -
- Views 361
- Downloads 17
Status of Herbal Drugs in Cardiovascular Research: A Review
Globally, cardiovascular diseases (CVD) constitute a leading cause of mortality. Heart disease in India occurs 10 to 15 years earlier than in the west. One fifth of the deaths in India are from coronary heart disease (...
Sex Variation of Motion Stereotypic Response among Adult Bengalee Population for the Operation of Some Simple Control-Display Units
Population stereotype point out to a long-term habit and well embedded knowledge of a particular population. This study was carried out to evaluate the variation in index of reversibility, response preference and respo...
Aflatoxin Contamination in Agricultural Commodities
Aflatoxin is a naturally occurring Mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. Aspergillus flavus is common and widespread in nature and is most often found when certain grains are grown under...
Antimicrobial analysis of Triphala and comparison with its individual constituents
Triphala, a well known ayurvedic formulation is used against number of ailments since ancient times. It consists of Emblica officinalis, Terminalia chebula and Terminalia bellerica in equal proportion. Triphala as a wh...
Comparaative study of Lipid profile and level of Antioxidant enzymes in cigarette smokers with non cigaretee smokers
Cigarette smoking is the serious health problems and most important avoidable cause of death in world. Worldwide more than 8 million people currently die each year from smoking half of them before of the age of 60. Eve...