Modulation of chemical signaling: current problems after four decades of research. Symposium on the occasion of the retirement of Professor Manfred Göthert. Bonn [Germany], June 10, 2006.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 2
Abstract
Authors and Affiliations
Interactions between neuroleptics and CYP2C6 in rat liver - in vitro and ex vivo study.
The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2C6 measured as a rate of warfarin 7-hydroxylation. The reaction was studied in control liver m...
Pulmonary endothelium in the perinatal period.
The pulmonary circulation is the only system in the body which does not have a dress rehearsal in utero. The pulmonary endothelium plays a pivotal role in ensuring that the resistance falls rapidly after birth so that th...
COX-2 as a target for cancer chemotherapy.
Cyclooxygenase-1 and -2 (COX-1/2) catalyze the initial step in the formation of prostaglandins. Very recently their role in carcinogenesis has become more evident. They influence apoptosis, angiogenesis, and invasion, an...
Characteristics of adrenaline-driven receptor-mediated signals in human microvessel-derived endothelial cells.
Adrenaline (0.001-1,000 muM) strongly stimulated adenosine-3',5'cyclic monophosphate (cAMP) generation in cultured human microvascular-derived endothelial cells (HMEC-1). Isoprenaline mimicked the action of adrenaline, w...
Protective effect of α-lipoic acid on oxidized low density lipoprotein-induced human umbilical vein endothelial cell injury.
The present study investigated the effect and possible mechanisms of α-lipoic acid (LA) in preventing endothelial cell injury induced by oxidized low-density lipoprotein (oxLDL). A model of human umbilical vein endotheli...