Moisturizing Kinetics of Maxrich, a Novel Moisturizing Formula Comprising of Xylitol and Xylitol-based Sugars such as Xylityglucoside and Anhydroxylitol
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 9
Abstract
Introduction: Polyols such as glycerol and xylitol are commonly implicated as moisturizers of the skin and other epithelial tissues. Xylitol was found to augment collagen formation, markedly suppress sodium lauryl sulfate-induced transepidermal water loss (TEWL), exert anti-irritant actions, and increase filaggrin expression and skin hydration. Materials and Methods: This was open-label, comparative, single-arm, pilot study involving 15 healthy volunteers who were prone to develop dry skin. Two test preparations were used in this study, one preparation was with ordinary cream base (control), while the other preparation was novel moisturizing formulation (MaxRich®) containing a complex of xylitol, xylitylglucoside, and anhydroxylitol. Primary objective of the study was to evaluate the hydration of skin, after application, of Maxrich® versus control over the duration of 24 h, while the secondary objective was to evaluate TEWL over the duration of 24 hours. MoistureMeter-SC (MMSC) and VapoMeter were used to measure skin hydration and TEWL, respectively. Results: MaxRich® was associated with a significant increase in skin hydration from baseline after 4 hours as shown by increase in mean MMSC reading (22.86 vs. 9.36; P < 0.05). The skin hydration was maintained above baseline throughout 24 hours which was statistically significant (P < 0.05) as shown by higher mean MMSC reading at 8, 12, and 24 h. Compared to control, MaxRich was associated with a significant increase in skin hydration (10.12 vs. 22.86, P < 0.05). Similarly, MaxRich® was associated with a significant decrease in transepidermal water loss compared to baseline after 4 h as shown by decrease in mean VapoMeter readings (9.22 vs. 5.99, P < 0.05). TEWL was maintained below baseline value as shown by lower mean VapoMeter readings at 8, 12, and 24 h. Compared to control, MaxRich® was associated with a significant decrease in TEWL (6.93 vs. 5.99, P < 0.05). Conclusion: Results of our study indicate that MaxRich®, a novel moisturizer containing xylitol, xylitylglucoside, and anhydroxylitol, is associated with intense, fast, and long-lasting moisturizing effect.
Authors and Affiliations
Gaurav A Deshmukh, Dhiraj S Dhoot, Hanmant Barkate
Keywords
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