MOLECULAR AND GENETIC FEATURES OF SQUAMOUS CELL CARCINOMA OF VULVAR CANCER DEPENDING ON HPV STATUS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 7
Abstract
The study included materials from 76 operations (110 paraffin blocks) that were not treated with neoadjuvant treatments, since preoperative exposure to tumors could significantly affect the results of the study, which is why these samples were not included in the study. It was found that the high viral load of HPV in RV correlates with the presence of metastases to the lymph nodes, invasion of the stroma, the degree of differentiation, as well as lymphovascular invasion, while it is in no way related to the stage of the disease. PD-L1 receptor expression is more often observed in HPV negative RV patients compared to HPV positive ones (7.8 vs. 3.7 p=0.03), while HPV positive patients were more likely to have STK11 mutation. At the same time, the PIK3CAE545 mutation occurred with the same frequency between the two groups of RV patients.
Authors and Affiliations
Navruzova Visola, Rasulova Nilufar, Nazarov Sherzod
Keywords
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- EP ID EP719427
- DOI 10.5281/zenodo.8137492
- Views 66
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