MOLECULAR APPROACH TO CLEFT LIP AND PALATE
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 2
Abstract
Cleft lip and palate is one of the most common birth anomalies world wide although its prevalence rate varies based on geographical origin, ethnic background, and socioeconomic status. The interaction of genetic factors and environmental factors such as maternal smoking, alcohol consumption, inadequate intake of folic acid, B6 and B12 vitamins during pregnancy can cause cleft lip and palate formation. Genetic studies on this disorder have investigated numerous candidate genes. MTHFR, MTR, MTRR, TGFβ and PVRL1 genes are important genes that cause cleft lip and palate. The inability to detect cleft lip and palate formation early is probably due to lack of knowledge of the mechanisms of gene expression patterns and action of effective signaling molecules that regulate lip and palate development during embryogenesis. Determination of the factors causing the cleft lip and palate etiology is very important in terms of prevention of cleft lip and palate formation and taking necessary precautions. In this review, it is aimed to determine the relationship between cleft lip palate disease and genetic factors.
Authors and Affiliations
Deniz AŞLAR ÖNER, Hakkı TAŞTAN
Keywords
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- EP ID EP702635
- DOI https://doi.org/10.18229/kocatepetip.678661
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