Molecular Biology of Breast Cancer in the Niger Delta Region of Nigeria: A Pilot Study
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 4
Abstract
Abstract: Breast cancer is the commonest cause of cancer related death among women globally. The incidence is lowest but increasing in Africa and accompanied by increased mortality. Different expression patterns of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth receptor (HER) 2 have been identified. The aim is to determine the molecular subtypes of breast cancer and evaluate their association with tumour characteristics such as age at presentation, stage of disease and grade of tumour.A 2 year prospective study of all patients that presented at University of Port Harcourt Teaching Hospital. Data was collected and analysed using the Statistical Package for Social Sciences (SPSS) version 17.0.Eighty six patients were seen during the study period and they were all females. Their ages ranged from 26 to 83 and the mean was 46.1 ± 14.3 years. Infiltrating ductal carcinoma was the commonest histological type, and seen in 78 (90.7%) patients. Triple negative was the commonest receptor subtype and observed in 40 (46.5%) patients. Breast cancer receptor subtype was significantly associated with stage and grade of tumour but not with age at presentation.Breast cancer in Nigerian women occurs relatively in younger women and most are triple negative and aggressive. Given the young age of onset and aggressiveness of this disease, it will be imperative to identify women at risk and increase the awareness, target screening and develop prevention strategies. Keywords: Breast cancer, molecular subtypes, Nigerian
Authors and Affiliations
Dodiyi-Manuel A, Athanasius BP
Keywords
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