MOLECULAR CHARACTERISATION AND DISSOLUTION PROFILE OF SOLID FORMULATIONS OF METFORMIN
Journal Title: Journal of Biopharmaceutics Sciences (JBS) - Year 2017, Vol 1, Issue 1
Abstract
In the present study, three novel multi-component salts of the anti-diabetic drug metformin, one with antiinflammatory drug diclofenac and two with pharmaceutically active co-crystal formers i.e., succinic acid and fumaric acid have been synthesized. The new solid phases have been preliminarily characterized by differential scanning calorimetry (DSC) and FT-IR analyses. The Single Crystal X-ray Diffraction (SCXRD) reveals the proton transfer from carboxylic acid group of co-formers to guanidine moiety metformin confirming the formation of new molecular salts. The molecular packing of all the salts is mainly supported by N−H···O– and N−H···N and hydrogen bonding interactions. The diclofenac salt of metformin interestingly shows a dissolution profile in a sustained release manner.
Authors and Affiliations
K. Anand Solomon, J. Satyanarayana Reddy, B. N. Vedhahari
Keywords
Related Articles
- EP ID EP404630
- DOI 10.26480/jbs.01.2017.20.24
- Views 106
- Downloads 0
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MOLECULAR CHARACTERISATION AND DISSOLUTION PROFILE OF SOLID FORMULATIONS OF METFORMIN
In the present study, three novel multi-component salts of the anti-diabetic drug metformin, one with antiinflammatory drug diclofenac and two with pharmaceutically active co-crystal formers i.e., succinic acid and fumar...