MOLECULAR CHARACTERISATION AND DISSOLUTION PROFILE OF SOLID FORMULATIONS OF METFORMIN
Journal Title: Journal of Biopharmaceutics Sciences (JBS) - Year 2017, Vol 1, Issue 1
Abstract
In the present study, three novel multi-component salts of the anti-diabetic drug metformin, one with antiinflammatory drug diclofenac and two with pharmaceutically active co-crystal formers i.e., succinic acid and fumaric acid have been synthesized. The new solid phases have been preliminarily characterized by differential scanning calorimetry (DSC) and FT-IR analyses. The Single Crystal X-ray Diffraction (SCXRD) reveals the proton transfer from carboxylic acid group of co-formers to guanidine moiety metformin confirming the formation of new molecular salts. The molecular packing of all the salts is mainly supported by N−H···O– and N−H···N and hydrogen bonding interactions. The diclofenac salt of metformin interestingly shows a dissolution profile in a sustained release manner.
Authors and Affiliations
K. Anand Solomon, J. Satyanarayana Reddy, B. N. Vedhahari
Keywords
Related Articles
- EP ID EP404630
- DOI 10.26480/jbs.01.2017.20.24
- Views 118
- Downloads 0
SIMULTANEOUS MULTIRESPONSE OPTIMIZATION OF THE MEDIUM FOR SUBMERGED FERMENTING IRPEX LACTEUS FR. MYCELIA USING DESIRABILITY FUNCTION
The aid of this paper was to optimize the fermentation medium of Irpex lacteus Mycelia for simultaneously enhancing the yields of mycelium, adenosine, intracellular polysaccharide, Cordyceps acid and protein. A sequentia...
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION COMBINED WITH PERCUTANEOUS INJECTION OF ETHANOL-LIPIODOL MIXTURE FOR TREATMENT OF HEPATOCELLULAR CARCINOMA: A NON-RANDOMIZED CONTROLLED STUDY OF 122 CASES
The aim is to evaluate effects and safety of the combination of transcather arterial chemoembolization (TACE) and percutaneous ethanol-lipiodol injection (PELI) for the treatment of unresectable hepatocellular carcinoma...
MOLECULAR CHARACTERISATION AND DISSOLUTION PROFILE OF SOLID FORMULATIONS OF METFORMIN
In the present study, three novel multi-component salts of the anti-diabetic drug metformin, one with antiinflammatory drug diclofenac and two with pharmaceutically active co-crystal formers i.e., succinic acid and fumar...
EXPERIMENTAL STUDY ON THE CIRCUMFERENTIAL RESIDUAL STRAINS IN AORTIC ARCH BASED ON CURVE LENGTH METHOD
In order to quantify residual strains in aortic arch, curve length method and corresponding computerized measurement of vessel images are presented. Distributions of geometric parameters and circumferential residual stra...
DEVELOPMENT OF PHARMACEUTICAL FOAM BASED TOPICAL DRUG DELIVERY SYSTEM
Topical drug delivery remains the popular choice of treatment for most of the dermatological diseases. Although the semisolids and liquids remains the choice of dosage forms, there is need of improved drug delivery syste...