Molecular Characterization of Chikungunya Virus in Serum- Relevance for Disease Management
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 2, Issue 5
Abstract
Chikungunya Virus (CHIKV) is an alphavirus with a positive sense single-stranded RNA genome of approximately 11.6kb, 60- 70nm diameter capsid and a phospholipid envelope. It is sensitive to desiccation and to temperatures above 58°C. It is a member of the Semliki Forest Virus complex. The transmission of this virus occurs with the bite of infected mosquitoes of the genus Aedes. In addition, blood born transmission is possible [1-3]. The incubation period ranges from 3 to 12 days. The onset is usually abrupt and the acute stage is characterized by sudden high fever, incapacitating arthralgia, myalgias and skin rash. Chronic arthritis may develop in the patients and is associated with fever, asthenia and exacerbation of arthralgia, inflammatory polyarthritis, and stiffness [4,5]. The Alphavirus group comprises of 28 viruses, six of which can cause human joint disorders-namely chikungunya virus, o’nyong-nyong virus (central Africa), Ross River and Barmah Forest viruses (Australia and the Pacific), Sindbis virus (cosmopolitan), and Mayaro virus (South America, French Guyana). These alphaviruses share certain antigenic determinants [6-9]
Authors and Affiliations
Komal Gupta, Vijaya Kuma, Narotam Sharma, Anita Rawat
Keywords
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- EP ID EP603713
- DOI 10.32474/AOICS.2018.02.000148
- Views 48
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