Molecular characterization of some new E. coli strains theoretically responsible for both intestinal and extraintestinal infections
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 6
Abstract
Strains of E. coli are divided into 3 major groups; commensal strains, diarrheagenic (intestinal) E. coli pathotypes and extraintestinal pathogenic E. coli. Extraintestinal pathogenic E. coli are unlike diarrheagenic pathotypes, they have not ability to cause intestinal disease in human, but they have normal ability for long-term colonization in the gut. This study aimed to spotlight on that intestinal and extraintestinal infections are not restricted to intestinal pathotypes and extraintestinal pathogenic E. coli, respectively. A total of 102 uropathogenic E. coli isolates were collected during 2012 and 2015. A multiplex PCR was used to detect phylogenetic groups, virulence factors for extraintestinal pathogenic E. coli and intestinal E. coli pathotypes genes. Results of this research showed that 12 (11.8%) uropathogenic E. coli isolates had genes that are theoretically responsible for intestinal diseases, were 10 of these isolates belonged to phylogentic group D and 2 isolates to phylogentic group A. We conclude from these results, this is the first report on the molecular characterization of E. coli that theoretically can cause both intestinal and extraintestinal infections simultaneously. The presence of these strains has a great impact on public health. More studies are necessary before definitive conclusions if these strains are a different clone that theoretically have ability to cause both intestinal and extraintestinal infections and belonged to phylogenetic groups other than A and D. Products of diarrheagenic genes in UPEC strains need further studies to detect their effects in intestinal infections.
Authors and Affiliations
Ghaleb Adwan| Department of Biology and Biotechnology, An-Najah National University, P.O. Box (7)-Nablus, Palestine, Corresponding e-mail: adwang@najah.edu, Kamel Adwan| Department of Biology and Biotechnology, An-Najah National University, P.O. Box (7)-Nablus, Palestine, Hiba Bourinee| Department of Biology and Biotechnology, An-Najah National University, P.O. Box (7)-Nablus, Palestine
Keywords
Related Articles
- EP ID EP11740
- DOI -
- Views 266
- Downloads 6
A Study on Dual Infections in Pyrexia Cases
Co-existing infections (Malaria and dengue) go undetected due to lack of clinical suspicion and overlapping symptoms. Co-existing infections are on the rise in tropics. This study is undertaken to assess the prevalence...
PATTERN OF ANTIMICROBIAL USE FOR URINARY TRACT INFECTION DURING PREGNANCY IN A TERTIARY CARE TEACHING HOSPITAL
Background: Urinary Tract Infection (UTI) may be classified as lower (cystitis and asymptomatic bacteriuria) or upper urinary tract infections (pyelonephritis). The recommended antibiotics for use in pregnancy for mana...
ROLE OF MRI IN EVALUATION OF PAINFUL KNEE
Introduction: Requests for knee Magnetic Resonance Imaging (MRI) are most often made when the patient presents with a painful knee. This pain might be due to trauma or infection or inflammation. Complete clinical exami...
NEW DRUGS IN THE PIPELINE: A REVIEW
Pharmacology is a rapidly advancing science. The essence of rational pharmacotherapeutics is to maximize the efficacy of a pharmaceutical interventional product for a specific indication, with a simultaneous minimizati...
Investigating the relationship between ageism and some demographic aspects in offering nursing care to elder patients of Al-zahra hospital, Isfahan
Objective and domain: patient care quality is influenced by many factors one of which can be nurse’s attitude toward the elderly. The present study conducted aiming at specifying the relationship between ageism and so...