MOLECULAR DOCKING STUDIES OF ORGANOSULFUR COMPOUNDS AND FLAVONOIDS OF ALLIUM SATIVUM AGAINST EGFR TO TREAT NON-SMALL CELL LUNG CANCER
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
Lung cancer is one of predominant cancer which leads to death in the developed and developing countries. 80% of lung cancer cases in India are reported as Non-Small Cell Lung Cancer (NSCLC). EGFR (Epidermal growth factor receptor) that belongs to the tyrosine kinase family (RTKs) is the key paradigm of molecular targeted therapy of lung cancer. Garlic (Allium sativum) is a common Indian spice that belongs to the Allium family, is capable of allowing cancer cell death normally, the process called apoptosis. The therapeutic effect of garlic is due to the presence of its bioactive constituents, including the organosulfur compounds and flavonoids. Molecular docking studies using AutoDock provide the comprehensive binding of bioactive compounds of garlic with EGFR that may lead to its effective inhibition. The current study paves the way for understanding the binding of garlic’s bioactive compounds against EGFR, and it can act as a potential lead molecule for the development of anti-cancer agents.
Authors and Affiliations
M. Razia et al.
Keywords
Related Articles
- EP ID EP627244
- DOI 10.13040/IJPSR.0975-8232.10(9).4186-93
- Views 90
- Downloads 0
QUALITY BY DESIGN: CHANGING OUTLOOK OF PHARMACEUTICAL DEVELOPMENT
The concept of quality by design (QbD) justifies the saying that, quality is not an act, it is a habit. This innovative and systematic approach to pharmaceutical development based on scientific principles has been a brea...
DEVELOPMENT AND VALIDATION OF A NEW HPLC-UV METHOD FOR SIMULTANEOUS ESTIMATION OF CETIRIZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN TABLET FORMULATION
A simple, rapid, and sensitive high-performance liquid chromatographic method with UV detection has been developed and validated according to the ICH guidelines for the quantitation of Cetirizine Hydrochloride (CET) and...
FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled i...
COMPARATIVE PHYLOGENETIC ANALYSIS OF METHYLERYTHRITOL-4-PHOSPHATE (MEP) PATHWAY GENES IN ASTERAECAE FAMILY
Stevioside glycosides (SGs) are a class of diterpene glycosides being produced by leaves of Stevia rebaudiana. Stevia is getting agricultural importance due to the production of natural sweetener steviol glycosides, also...
UNCOMMON SIDE EFFECTS OF COMMONLY USED ANTI-DIABETICS: TIME TO MONITOR THEM
Diabetes, a chronic endocrine metabolic disorder, is managed using several anti-diabetic medications. Being a chronic disease requiring lifelong medications, the long-term safety profile and patient acceptance are crucia...