Molecular Evolution of the Allergic Rhinitis Associated Gene Family IL-33 in Mammalian Species
Journal Title: Scholars Journal of Agriculture and Veterinary Sciences - Year 2015, Vol 2, Issue 1
Abstract
Abstract: Interleukin-33 (IL-33) is an IL-1-like cytokine ligand for the IL-1 receptor-related protein ST2. Allergic rhinitis (AR) is one of the most common allergic inflammatory diseases. Globally, more than 600 million persons have AR. AR is divided into categories: seasonal and peren-nial. The way genomic histories drove the evolution of the IL-33 family in mammalian species was described; IL-33 genes were searched in nine mammalian such as Bos taurus, Sus scrofa, Oryctolagus cuniculus,and the Ovis aries and then through phylogenetic analysis. Microsynteny analysis was made based on genomic segments containing the IL-33 genes. Some pairs turned out to conform with syntenic genome regions, while others corresponded to those that were inverted, expanded, or contracted after the divergence of mammalians. Besides, we dated their duplications by Ks analysis and demonstrated that all the blocks were formed after the split; we observed Ka/Ks ratios representing strong purifying selections in the four mammalian species which might have been followed by gene loss and rearrangement. Keywords: Allergic rhinitis, Syntenic homology, Genetic variation, IL-33 Protein
Authors and Affiliations
Renjie Song, Feihu Wu, Ling Zhu, Gang Liu
Keywords
Related Articles
- EP ID EP380836
- DOI -
- Views 73
- Downloads 0
Isolation, Characterization and Antibiotics Sensitivity Pattern of Staphylococcus aureus from Man, Animal and Environment
Staphylococcus aureus, an opportunistic pathogen, is a gram positive, spherical or ovoid bacterium that causes serious diseases in men and animals. The occurrence and etiological significance of Staphylococcus aureus was...
Mineral Status of Feeds, Fodder and Dairy Animals in Jalgaon District of Maharashtra State
A study was carried out to assess the dietary status of macro and micro-minerals of milch animals in Jalgaon district of Maharashtra, for developing area specific mineral mixture. Feed and fodder samples were collected a...
Effect of whey protein concentrate on quality and shelf life of buffalo meat emulsion sausage
Incorporation of whey protein concentrate (WPC) at a level of 1, 2, 3 and 4% in buffalo meat was investigated for production, quality characteristic and shelf life of buffalo meat emulsion sausage (ES). Quality of emulsi...
Growth Performance of Nellore Brown Strain of Sheep
Abstract: Nellore breed is the tallest sheep bread of India and widely distributed in the Andhra Pradesh. An attempt was made to study the growth performance of Nellore sheep at various growth stages under organized farm...
Clinical, Cytological and Chemotherapy aspects of Plasmacytoid Sticker Tumor in a dog – case report
Sticker tumor or transmissible venereal tumor (TVT) is a contagious cancer of high prevalence in dogs which spread usually occurs through sexual contact. Macroscopically are cauliflower-like and can be pedunculated, nodu...