MOLECULAR GENETICS OF NON-SYNDROMIC CLEFTS REVISITED
Journal Title: International Journal of Genetics - Year 2011, Vol 3, Issue 1
Abstract
Cleft of the lip and palate (CL/P) are generally divided in to two groups, isolated cleft palate and cleft with or without cleft palate representing a heterogeneous group of disorders affecting the upper lip and the roof the mouth. Non-syndromic cleft lip and palate incidence is 1 in 700 to 1000 live babies with ethnic and geographic variations. Various independent association and linkage studies using different populations have identified several loci. Numerous genes have been reported in studies demonstration associations and/or linkage of the cleft lip and palate phenotypes to alleles of microsatellite markers and single nucleotide polymorphisms within specific genes that regulate transcription factor, growth factor, cell signalling and detoxification metabolisms. Currently, efforts are focussed to identify the genes and genetic variations within the numerous candidate genes that have been found to associate with the expression of the orofacial cleft phenotype. In conclusion, the genetic basis of CL/P is still contentious because of genetic complexity of clefting.
Authors and Affiliations
M. RAJASEKHAR, L. SAIKRISHNA, L. V. K. S. BHASKAR
Keywords
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- EP ID EP170154
- DOI 10.9735/0975-2862.3.1.23-34
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